Coronary Artery Disease - Omega-3 Fatty Acids

Omega-3 Fatty Acids

The benefit of fish oil is controversial with conflicting conclusions reached by a negative meta-analysis on studies using traditional omega-3 products of randomized controlled trials by the international Cochrane Collaboration and a partially positive systematic review by the Agency for Healthcare Research and Quality. Since these two reviews, a randomized controlled trial reported a remarkable reduction on coronary events in Japanese hypercholesterolemic patients, and a later subanalysis suggested that the protective effect of highly purified EPA (E-EPA) is even more pronounced in Japanese diabetics even though their intake of fish is high.

Omega-3 fatty acids are also found in some plant sources including flax seed oil, hemp seed oil, and walnuts. The parent Omega-3 ALA, while very important for general health, needs to be converted in the liver to EPA and only 5% is converted, making the benefits unclear for coronary artery disease specifically.

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