Physiology
The principal physiological function of the corneal endothelium is to allow leakage of solutes and nutrients from the aqueous humor to the more superficial layers of the cornea while at the same time actively pumping water in the opposite direction, from the stroma to the aqueous. This dual function of the corneal endothelium is described by the "pump-leak hypothesis." Since the cornea is avascular, which renders it optimally transparent, the nutrition of the corneal epithelium, stromal keratocytes, and corneal endothelium must occur via diffusion of glucose and other solutes from the aqueous humor, across the corneal endothelium. The corneal endothelium then actively transports water from the stromal-facing surface to the aqueous-facing surface by an interrelated series of active and passive ion exchangers. Critical to this energy-driven process is the role of Na+/K+ATPase and carbonic anhydrase. Bicarbonate ions formed by the action of carbonic anhydrase are translocated across the cell membrane, allowing water to passively follow.
Read more about this topic: Corneal Endothelium
Famous quotes containing the word physiology:
“A physician’s physiology has much the same relation to his power of healing as a cleric’s divinity has to his power of influencing conduct.”
—Samuel Butler (1835–1902)
“If church prelates, past or present, had even an inkling of physiology they’d realise that what they term this inner ugliness creates and nourishes the hearing ear, the seeing eye, the active mind, and energetic body of man and woman, in the same way that dirt and dung at the roots give the plant its delicate leaves and the full-blown rose.”
—Sean O’Casey (1884–1964)
“Now the twitching stops. Now you are still. We are through with physiology and theology, physics begins.”
—Alfred Döblin (1878–1957)