Constantinescu (or Constantinesco, its Francisized version), a common Romanian family name, may refer to one of the following:
- Alecu Constantinescu, journalist and communist activist
- Alexandru Constantinescu-Porcu, politician, and his son Ata Constantinescu, politician and political prisoner
- Constantin Constantinescu-Claps, General
- Dan Constantinescu, politician
- Dumitru Constantinescu-Teleormăneanu, satirist
- Emil Constantinescu, former President of Romania
- George Constantinescu, scientist and inventor
- Ion Constantinescu, Brigadier-General
- Liviu Constantinescu, geophysicist
- Mac Constantinescu, sculptor
- Marian Constantinescu, football player
- Marina Constantinescu, theatre critic and television personality
- Miron Constantinescu, sociologist, historian, and communist politician
- Mitiţă Constantinescu, economist
- Nicholas Constantinesco, historian
- Nicu Constantinescu, former mayor of Buzău
- Paul Constantinescu, composer
- Petre Constantinescu-Iaşi, historian and communist politician
- Pompiliu Constantinescu, literary historian
- Ştefan Constantinescu, painter
- Tancred Constantinescu, general and politician
- Vlad Constantinesco, jurist
- Vladimir Constantinescu, Major-General