CMD may refer to:
- Camden Road railway station, a station in London, England (National Rail code: CMD)
- Canis Major Dwarf, a small galaxy orbiting the Milky Way
- Catastrophe à moyens dépassé, a French phrase meaning "disaster without sufficient rescue means"
- Center for Media and Democracy, an American media research group
- Central meridian distance, a geographical term
- Chairman and Managing Director, a managing director who is also the chairman of the same company
- Cincinnati Mighty Ducks, an American ice hockey team
- Congenital muscular dystrophy, a form of muscular dystrophy that is present from birth
- Coleg Meirion-Dwyfor, a college in Gwynedd, Wales
- Color-magnitude diagram, a scatter-graph of stars used by astronomers
- Creative Micro Designs, a computer hardware company
CMD is commonly used to mean "command":
- Command (computing), an abbreviation commonly used in computing
- Command key, a modifier key present on Apple Keyboards
- Command Prompt, the command-line interpreter on Windows operating systems
- CMD file (CP/M), the filename extension used by executable programs