CLR may refer to:
- Mercedes-Benz CLR, a racing car
- Calcium Lime Rust, a household cleaning product
- California Law Review, a publication by the UC Berkeley School of Law
- The Circle of Liberal Reformers, a political party in Gabon
- Combat Logistics Regiment, a type of United States Marine Corps regiment
- Command, Leadership, Resource management, another acronym for Cockpit Resource Management
- Common Language Runtime, the virtual machine component of Microsoft .NET
- Commonwealth Law Reports, reports of decisions of the High Court of Australia
- Compagnie Luxembourgeoise de Radiodiffusion, a Luxembourg-based radio broadcaster now part of RTL Group
- A nickname for Introduction to Algorithms by Cormen, Leiserson, and Rivest
- Cliff Hatfield Memorial Airport, an airport in Calipatria, California
- CLR (formerly Computer Language Research), a subsidiary of Thomson Reuters Tax & Accounting
- Compensation Log Record, a type of database log record