Chronic Granulomatous Disease - History

History

This condition was first described in 1954 by Janeway, who reported five cases of the disease in children. In 1957 it was further characterized as "a fatal granulomatosus of childhood". The underlying cellular mechanism that causes chronic granulomatous disease was discovered in 1967, and research since that time has further elucidated the molecular mechanisms underlying the disease. Use of antibiotic prophylaxis, surgical abscess drainage, and vaccination lead to the term "fatal" being dropped from the name of the disease as children survived into adulthood. The oldest person to suffer from Chronic Granulomatos Disease was Mr. Jackie Ray Johnson of Fredericksburg, Virginia who died in 2002 at the age of 63.

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