Clinical Significance
A changed migratory potential of cells has relatively high importance in the development of several clinical symptoms and syndromes. Altered chemotactic activity of extracellular (e.g. Escherichia coli) or intracellular (e.g. Listeria monocytogenes) pathogens itself represents a significant clinical target. Modification of endogenous chemotactic ability of these microorganisms by pharmaceutical agents can decrease or inhibit the ratio of infections or spreading of infectious diseases. Apart from infections, there are some other diseases where impaired chemotaxis is the primary etiological factor, as in Chediak-Higashi syndrome where giant intracellular vesicles inhibit normal migration of cells.
| Type of disease | Chtx. increased | Chtx. decreased |
|---|---|---|
| Infections | inflammations | AIDS, Brucellosis |
| Chtx. results the disease | - | Chediak-Higashi syndrome, Kartagener syndrome |
| Chtx. is affected | atherosclerosis, arthritis, periodontitis, psoriasis, reperfusion injury, metastatic tumors | multiple sclerosis, Hodgkin disease, male infertility |
| Intoxications | asbestos, benzpyrene | salts of Hg and Cr, ozone (O3) |
Read more about this topic: Chemotaxis
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