Chain Reaction (film) - Cast

Cast

• Keanu Reeves as Eddie Kasalivich: A machinist working on a team from the University of Chicago. He is forced on the run with Dr. Lily Sinclair when someone frames him for the murder of his boss, Dr. Alistair Barkley, and the destruction of his laboratory. He must work to clear their names before they are captured or killed.
• Morgan Freeman as Dr. Paul Shannon: The enigmatic leader of the project at the University of Chicago. His motives are unclear throughout the movie, but he advises Eddie to turn himself into the authorities. It is later disclosed that he is actually the head of the entire program that includes Lyman, who tries to have the research team killed. A scene with Agents Ford and Doyle and the ending suggests Paul is CIA.
• Rachel Weisz as Dr. Lily Sinclair: Physicist working with Dr. Alistair Barkley. She goes on the run with Eddie when they are framed for Alistair's murder and the destruction of his laboratory.
• Fred Ward as FBI Agent Leon Ford: In charge of the investigation to discover the cause of the destruction of the laboratory. Initially focuses on Eddie and Lily, but soon suspects the involvement of larger government organizations.
• Kevin Dunn as FBI Agent Doyle: Ford's assistant in the investigation. He helps Ford track down Eddie, Lily and later, C-Systems.
• Brian Cox as Lyman Earl Collier: Chairman of C-Systems Research. The person behind the conspiracy to keep the Hydrogen power plant a secret.
• Joanna Cassidy as Maggie McDermott: An old friend of Eddie's who lives in an observatory in Wisconsin. Eddie and Lily head to her place after a warrant is issued for their arrest.
• Nicholas Rudall as Dr. Alistair Barkley: Head of the project to develop energy from water. He is suffocated in an attempt to frame Eddie for the explosion.
• Tzi Ma as Dr. Lu Chen: Project Manager on the Hydrogen Project and Dr. Barkley's right hand man. When Alistair is killed, Dr. Chen is kidnapped and forced to work at C-Systems under Lyman Collier.
• Eddie Bo Smith Jr. as Yusef Reed: Right hand man for Collier at C-Systems Research. First seen as the getaway driver of the suspicious van, he overshadows both Eddie and Lily later on during their flight from the law.

Michael Shannon and Neil Flynn make appearances as a van driver and a cop, respectively.