Conclusion
In summary, ChIP-seq offers an alternative to ChIP-chip. STAT1 experimental ChIP-seq data have a high degree of similarity to results obtained by ChIP-chip for the same type of experiment, with >64% of peaks in shared genomic regions. Because the data are sequence reads, ChIP-seq offers a rapid analysis pipeline (as long as a high-quality genome sequence is available for read mapping, and the genome doesn't have repetitive content that confuses the mapping process) as well as the potential to detect mutations in binding-site sequences, which may directly support any observed changes in protein binding and gene regulation.
Read more about this topic: Ch IP-sequencing
Famous quotes containing the word conclusion:
“We must not leap to the fatalistic conclusion that we are stuck with the conceptual scheme that we grew up in. We can change it, bit by bit, plank by plank, though meanwhile there is nothing to carry us along but the evolving conceptual scheme itself. The philosopher’s task was well compared by Neurath to that of a mariner who must rebuild his ship on the open sea.”
—Willard Van Orman Quine (b. 1908)
“The chess pieces are the block alphabet which shapes thoughts; and these thoughts, although making a visual design on the chess-board, express their beauty abstractly, like a poem.... I have come to the personal conclusion that while all artists are not chess players, all chess players are artists.”
—Marcel Duchamp (1887–1968)
“So this
Is man; so—what better conclusion is there—
The day will not follow night, and the heart
Of man has a little dignity, but less patience
Than a wolf’s,”
—Allen Tate (1899–1979)