Substances Known To Induce Ceramide Generation
- Anandamide
- Tetrahydrocannabinol and other Cannabinoids
- TNF-alpha
- Fas ligand
- Endotoxin
- Chemotherapeutic agents
- 1,25 dihydroxy vitamin D
- gamma interferon
- heat
- ionizing radiation
- Ceramidase Inhibitors
It is interesting to note that the substances that can cause ceramide to be generated tend to be stress signals that can cause the cells to go into programmed cell death. Ceramide thus acts as an intermediary signal that connects the external signal to the internal metabolism of the cells.
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