CD4+ T Cells and Antitumor Immunity - CD8+ T Cells and Antitumour Immunity

CD8+ T Cells and Antitumour Immunity

Historically, much more attention and funding has been devoted to the role of CD8+ T cells in antitumor immunity, rather than to CD4+ T cells. This can be attributed to a number of things; CD4+ T cells respond only to presentation of antigens by MHC class II, however, most cells express only MHC class I; second, CD8+ T cells, upon being presented with antigen by MHC class I, can directly kill the cancerous cell, through mechanisms which will not be discussed in this article, but which have been well categorized; (See Abbas and Lichtman, 2005) finally, there is simply a more widespread understanding and knowledge of MHC class I tumor antigens, while MHC class II antigens remain somewhat obscure.(Pardol and Toplain, 1998).
It was believed that CD4+ T cells were not involved directly in antitumour immunity, but rather functioned simply in the priming of CD8+ T cells, through activation antigen presenting cells (APCs) and increased antigen presentation on MHC class I, as well as secretion of excitatory cytokines such as IL-2 (Pardol and Toplain, 1998, Kalams and Walker, 1998, Wang 2001).