Clinical Significance
The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications.
The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.
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“History is the interpretation of the significance that the past has for us.”
—Johan Huizinga (1872–1945)