Cd135

CD135

Identifiers Symbols FLT3; CD135; FLK-2; FLK2; STK1 External IDs OMIM: 136351 MGI: 95559 HomoloGene: 3040 ChEMBL: 1974 GeneCards: FLT3 Gene EC number 2.7.10.1

Gene Ontology
Molecular function	• transmembrane receptor protein tyrosine kinase activity • cytokine receptor activity • vascular endothelial growth factor-activated receptor activity • protein binding • ATP binding • protein homodimerization activity • phosphatidylinositol 3-kinase binding
Cellular component	• endoplasmic reticulum lumen • integral to plasma membrane • cell surface
Biological process	• leukocyte homeostasis • myeloid progenitor cell differentiation • pro-B cell differentiation • pro-T cell differentiation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell proliferation • negative regulation of cell proliferation • positive regulation of phosphatidylinositol 3-kinase cascade • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • hemopoiesis • B cell differentiation • common myeloid progenitor cell proliferation • vascular endothelial growth factor signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • regulation of apoptotic process • positive regulation of MAP kinase activity • positive regulation of MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • negative regulation of B cell differentiation • lymphocyte proliferation • protein autophosphorylation • cellular response to cytokine stimulus • dendritic cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2322 14255 Ensembl ENSG00000122025 ENSMUSG00000042817 UniProt P36888 Q00342 RefSeq (mRNA) NM_004119.2 NM_010229.2 RefSeq (protein) NP_004110.2 NP_034359.2 Location (UCSC) Chr 13:
28.58 – 28.67 Mb Chr 5:
147.33 – 147.4 Mb PubMed search

Cluster of differentiation antigen 135 (CD135) also known as Fms-like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene. Flt3 is a cytokine receptor which belongs to the receptor tryrosin kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (Flt3L).