CD117
| Gene Ontology | |
|---|---|
| Molecular function | • protease binding • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • receptor signaling protein tyrosine kinase activity • stem cell factor receptor activity • protein binding • ATP binding • cytokine binding • protein homodimerization activity • metal ion binding |
| Cellular component | • extracellular space • nucleus • cytoplasm • plasma membrane • external side of plasma membrane • integral to membrane |
| Biological process | • activation of MAPK activity • ovarian follicle development • myeloid progenitor cell differentiation • lymphoid progenitor cell differentiation • immature B cell differentiation • dendritic cell cytokine production • mast cell chemotaxis • glycosphingolipid metabolic process • inflammatory response • signal transduction • intracellular protein kinase cascade • spermatogenesis • spermatid development • positive regulation of cell proliferation • regulation of cell shape • male gonad development • response to radiation • positive regulation of gene expression • positive regulation of phospholipase C activity • positive regulation of phosphatidylinositol 3-kinase cascade • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • stem cell maintenance • signal transduction by phosphorylation • lamellipodium assembly • hemopoiesis • T cell differentiation • erythrocyte differentiation • melanocyte differentiation • actin cytoskeleton reorganization • mast cell cytokine production • embryonic hemopoiesis • germ cell programmed cell death • megakaryocyte development • Fc receptor signaling pathway • Kit signaling pathway • erythropoietin-mediated signaling pathway • regulation of cell proliferation • positive regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of tyrosine phosphorylation of Stat5 protein • negative regulation of programmed cell death • mast cell degranulation • positive regulation of MAPK cascade • pigmentation • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of JAK-STAT cascade • protein autophosphorylation • regulation of developmental pigmentation • digestive tract development • stem cell differentiation • detection of mechanical stimulus involved in sensory perception of sound • positive regulation of sequence-specific DNA binding transcription factor activity • cell chemotaxis • mast cell differentiation • mast cell proliferation • cellular response to thyroid hormone stimulus • melanocyte migration • melanocyte adhesion |
| Sources: Amigo / QuickGO | |
55.52 – 55.61 Mb
75.57 – 75.66 Mb
Mast/stem cell growth factor receptor (SCFR), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit.
Read more about CD117: Cell Surface Marker, Function, Mobilization, Role in Cancer, Diagnostic Relevance, Interactions