Caruso is an Italian surname and may refer to:
- Anthony Caruso (disambiguation)
- Carmine Caruso (1904–1987), American brass instrument pedagog
- Dave Caruso (born 1982), American ice hockey goaltender
- David Caruso (born 1956), American actor
- Dee Caruso (1928-2012) American writer for TV and film
- Domenico Caruso (born 1933), Italian poet and writer
- D. J. Caruso (born 1965), American film director
- Enrico Caruso (1873–1921), Italian opera singer
- Henry Caruso, American businessman, founder of Dollar Rent A Car
- Leandro Caruso (born 1982), Argentine footballer
- Mark J. Caruso (born 1957), attorney and State Representative in New Mexico Legislature
- Michael Caruso (racing driver) (born 1983), Australian racing driver
- Pietro Caruso an Italian fascist involved in the Fosse Ardeatine mass murder
- Robert Caruso, a director of commercials, video, and film
It may also refer to:
- Caruso (band), an Irish indie rock band
- "Caruso" (song), a song written by Lucio Dalla
- Caruso Affiliated, a real estate development company in Los Angeles, California
- Caruso Sauce, a Uruguayan recipe
- Caruso Middle School, a middle school in Illinois
Uncapitalized, caruso is an Italian noun (from Sicilian "carusu", dear boy) referring to a mine laborer