Cardini is an Italian surname. Notable people with that surname include:
- Caesar Cardini (1896–1956), Italian American restaurateur, chef and hotel owner
- Franco Cardini (* 1940), Italian historian
- Giancarlo Cardini (* 1940), Italian pianist and composer
- Ignazio Cardini (1566–1602), Corsican doctor, naturalist and humanist
- Leobardo Cardini (* 1905, date of death unknown), Mexican Olympic fencer
- Richard Valentine Pitchford alias „Cardini“ (1895–1973), British magician
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