Cardinal Sin may refer to:
- Jaime Sin, former Archbishop of Manila
- Seven deadly sins, often called the "cardinal sins"
- Mortal sin (Catholicism)
- Cardinal Sin (band), a black metal band formed in 1995
- "Cardinal Sin", a song by Black Sabbath from their 1994 album Cross Purposes
- "The Cardinal Sin", a song by Dead Can Dance from their 1985 album Spleen and Ideal
- The three Cardinal Sins (Judaism), see Self-sacrifice under Jewish law
- The Cardinal Sins, a novel by Andrew M. Greeley
Famous quotes related to cardinal sin:
“In nothing was slavery so savage and relentless as in its attempted destruction of the family instincts of the Negro race in America. Individuals, not families; shelters, not homes; herding, not marriages, were the cardinal sins in that system of horrors.”
—Fannie Barrier Williams (1855–1944)