Major Currents
| Ion | Current (I) | α subunit protein | α subunit gene | Phase / role |
|---|---|---|---|---|
| Na+ | INa | NaV1.5 | SCN5A | 0 |
| Ca2+ | ICa(L) | CaV1.2 | CACNA1C | 0-2 |
| K+ | Ito1 | KV4.2/4.3 | KCND2/KCND3 | 1, notch |
| K+ | IKs | KV7.1 | KCNQ1 | 2,3 |
| K+ | IKr | KV11.1 (hERG) | KCNH2 | 3 |
| K+ | IK1 | Kir2.1/2.2/2.3 | KCNJ2/KCNJ12/KCNJ4 | 3,4 |
| Na+, Ca2+ | INaCa | 3Na+-1Ca2+-exchanger | NCX1 (SLC8A1) | ion homeostasis |
| Na+, K+ | INaK | 3Na+-2K+-ATPase | ATP1A | ion homeostasis |
| Ca2+ | IpCa | Ca2+-transporting ATPase | ATP1B | ion homeostasis |
Read more about this topic: Cardiac Action Potential
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