C-Raf
Gene Ontology | |
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Molecular function | • protein kinase activity • protein serine/threonine kinase activity • MAP kinase kinase kinase activity • protein binding • ATP binding • Ras GTPase binding • mitogen-activated protein kinase kinase binding • identical protein binding • metal ion binding • protein heterodimerization activity |
Cellular component | • nucleus • cytoplasm • mitochondrial outer membrane • cytosol • plasma membrane • pseudopodium |
Biological process | • MAPK cascade • activation of MAPKK activity • response to hypoxia • protein phosphorylation • apoptotic process • cytoskeleton organization • signal transduction • epidermal growth factor receptor signaling pathway • activation of adenylate cyclase activity • small GTPase mediated signal transduction • Ras protein signal transduction • synaptic transmission • axon guidance • heart development • blood coagulation • cell proliferation • negative regulation of cell proliferation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • platelet activation • negative regulation of protein complex assembly • positive regulation of peptidyl-serine phosphorylation • regulation of Rho protein signal transduction • wound healing • regulation of apoptotic process • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of cell differentiation • nerve growth factor receptor signaling pathway • regulation of cell motility |
Sources: Amigo / QuickGO |
12.63 – 12.71 Mb
115.62 – 115.68 Mb
RAF proto-oncogene serine/threonine-protein kinase also known as proto-oncogene c-RAF or simply c-Raf is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade. C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases.
Read more about C-Raf: Function, Discovery and Role in Cancer, Regulation of Raf Kinase Activity, Targets of Raf-1, Interactions