Btg2

BTG2

Identifiers Symbols BTG2; PC3; TIS21 External IDs OMIM: 601597 MGI: 108384 HomoloGene: 31406 GeneCards: BTG2 Gene

Gene Ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • protein binding
Biological process	• DNA repair • protein methylation • response to DNA damage stimulus • negative regulation of cell proliferation • associative learning • response to mechanical stimulus • anterior/posterior pattern specification • response to organic cyclic compound • dentate gyrus development • central nervous system neuron development • neuron projection development • negative regulation of apoptotic process • response to peptide hormone stimulus • response to electrical stimulus • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • negative regulation of neural precursor cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7832 12227 Ensembl ENSG00000159388 ENSMUSG00000020423 UniProt P78543 Q04211 RefSeq (mRNA) NM_006763 NM_007570 RefSeq (protein) NP_006754 NP_031596 Location (UCSC) Chr 1:
203.27 – 203.28 Mb Chr 1:
134.08 – 134.08 Mb PubMed search

Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene (B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.