BTG2

BTG2

Identifiers Symbols BTG2; PC3; TIS21 External IDs OMIM: 601597 MGI: 108384 HomoloGene: 31406 GeneCards: BTG2 Gene

Gene Ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • protein binding
Biological process	• DNA repair • protein methylation • response to DNA damage stimulus • negative regulation of cell proliferation • associative learning • response to mechanical stimulus • anterior/posterior pattern specification • response to organic cyclic compound • dentate gyrus development • central nervous system neuron development • neuron projection development • negative regulation of apoptotic process • response to peptide hormone stimulus • response to electrical stimulus • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • negative regulation of neural precursor cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7832 12227 Ensembl ENSG00000159388 ENSMUSG00000020423 UniProt P78543 Q04211 RefSeq (mRNA) NM_006763 NM_007570 RefSeq (protein) NP_006754 NP_031596 Location (UCSC) Chr 1:
203.27 – 203.28 Mb Chr 1:
134.08 – 134.08 Mb PubMed search

Protein BTG2 also known as BTG family member 2 or NGF-inducible anti-proliferative protein PC3 or NGF-inducible protein TIS21, is a protein that in humans is encoded by the BTG2 gene (B-cell translocation gene 2) and in other mammals by the homologous Btg2 gene. This protein controls cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors.

The protein BTG2 is the human homolog of the PC3 (pheochromocytoma cell 3) protein in rat and of the Tis21 (tetradecanoyl phorbol acetate-inducible sequence 21) protein in mouse. Tis21 had been originally isolated as a sequence induced by TPA in mouse fibroblasts, whereas PC3 was originally isolated as sequence induced at the beginning of neuron differentiation; BTG2 was then isolated in human cells as sequence induced by p53 and DNA damage.

The protein encoded by the gene BTG2 (which is the official name assigned to the gene PC3/Tis21/BTG2) is a member of the BTG/Tob family (that comprises six proteins BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2).This family has structurally related proteins that appear to have antiproliferative properties. In particular, the BTG2 protein has been shown to negatively control a cell cycle checkpoint at the G₁ to S phase transition in fibroblasts and neuronal cells by direct inhibition of the activity of cyclin D1 promoter.