Brca2

BRCA2

Identifiers Symbols BRCA2; BRCC2; BROVCA2; FACD; FAD; FAD1; FANCB; FANCD; FANCD1; GLM3; PNCA2 External IDs OMIM: 600185 MGI: 109337 HomoloGene: 41 GeneCards: BRCA2 Gene

Gene Ontology
Molecular function • protease binding
• single-stranded DNA binding
• histone acetyltransferase activity
• protein binding
• H3 histone acetyltransferase activity
• H4 histone acetyltransferase activity
• gamma-tubulin binding
Cellular component • nucleus
• nucleoplasm
• nucleolus
• cytoplasm
• centrosome
• secretory granule
• BRCA2-MAGE-D1 complex
• protein complex
Biological process • double-strand break repair via homologous recombination
• oocyte maturation
• inner cell mass cell proliferation
• DNA repair
• nucleotide-excision repair
• double-strand break repair
• DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
• regulation of S phase of mitotic cell cycle
• male meiosis I
• spermatogenesis
• brain development
• cell aging
• response to nutrient
• female gonad development
• response to X-ray
• response to UV-C
• response to gamma radiation
• hemopoiesis
• mammary gland development
• homologous chromosome orientation involved in meiotic metaphase I plate congression
• response to estradiol stimulus
• regulation of cytokinesis
• cell cycle cytokinesis
• negative regulation of mammary gland epithelial cell proliferation
• multicellular organism growth
• intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
• histone H3 acetylation
• histone H4 acetylation
• positive regulation of transcription, DNA-dependent
• positive regulation of mitotic cell cycle
• replication fork protection
• centrosome duplication
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 675 12190 Ensembl ENSG00000139618 ENSMUSG00000041147 UniProt P51587 P97929 RefSeq (mRNA) NM_000059.3 NM_001081001.1 RefSeq (protein) NP_000050.2 NP_001074470.1 Location (UCSC) Chr 13:
32.89 – 32.97 Mb Chr 5:
150.52 – 150.57 Mb PubMed search
BRCA2 repeat
crystal structure of a rad51-brca2 brc repeat complex
Identifiers
Symbol BRCA2
Pfam PF00634
InterPro IPR002093
SCOP 1n0w
SUPERFAMILY 1n0w
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
BRCA-2 helical
structure of a brca2-dss1 complex
Identifiers
Symbol BRCA-2_helical
Pfam PF09169
InterPro IPR015252
SCOP 1iyj
SUPERFAMILY 1iyj
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
structure of a brca2-dss1 complex
Identifiers
Symbol BRCA-2_OB1
Pfam PF09103
InterPro IPR015187
SCOP 1iyj
SUPERFAMILY 1iyj
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
structure of a brca2-dss1 complex
Identifiers
Symbol BRCA-2_OB3
Pfam PF09104
InterPro IPR015188
SCOP 1iyj
SUPERFAMILY 1iyj
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
Tower domain
structure of a brca2-dss1 complex
Identifiers
Symbol Tower
Pfam PF09121
InterPro IPR015205
SCOP 1mje
SUPERFAMILY 1mje
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

BRCA2 (breast cancer type 2 susceptibility protein) is a protein found inside cells. In humans, the instructions to make this protein are carried by a gene, also called BRCA2. BRCA2 belongs to the tumor suppressor gene family, and orthologs have been identified in most mammals for which complete genome data are available. The protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks.

Read more about Brca2.