Botero is a surname of Italian origin common in Colombia. Its meaning in English is "boat maker." The surname can refer to the following people:
- Alejandro Botero (born 1980), Colombian footballer
- Beatriz Elena Uribe Botero, Colombian politician
- Fernando Botero (born 1932), Colombian figurative artist
- Fernando Botero Zea (born 1956), Colombian politician
- Giovanni Botero (c.1544–1617), Italian thinker, priest, poet, and diplomat
- Joaquín Botero (born 1977), Bolivian footballer
- Juan Carlos Botero, Colombian legal researcher
- Juan Sebastián Botero (born 1986), Colombian-American footballer
- Naty Botero, Colombian model
- Santiago Botero (born 1972), Colombian cyclist
- Samuel Botero (born 1945), Colombian American Designer