Bonomi is the name of several notable persons:
- Andrea Bonomi, footballer
- Beniamino Bonomi
- Carlo Bonomi (born 1937), Italian voice actor
- Ignatius Bonomi (1787-1870), architect
- Ivanoe Bonomi (1873-1951), Italian prime minister
- Joseph Bonomi the Elder (1739-1808), architect
- Joseph Bonomi the Younger (1796-1878), sculptor