Bonifacio can refer to:
- People
- Bonifacio Avila (b. 1950), a Colombian boxer
- José Bonifácio de Andrada e Silva, (c. 1763–1838), a Portuguese statesman
- Andrés Bonifacio (1863–1887), a Philippine revolutionary leader
- Boniface I of Montferrat (c. 1150-1207), a Marquess of Montferrat and the leader of the Fourth Crusade
- Emilio Bonifacio (b. 1985), a Major League Baseball player for the Toronto Blue Jays
- Boniface, a Christian saint.
- Places
- Bonifacio, Corse-du-Sud, a town in Corsica, France
- Strait of Bonifacio, separating Corsica from Sardinia
- Bonifacio, Misamis Occidental, a municipality in the Philippines
- Bonifacio (Costa Rica), a community in Costa Rica.
- Fort Bonifacio (also Bonifacio Global City or The Global City) is a highly urbanized district in Taguig City, Metro Manila, Philippines.
- Ships
- BRP Andres Bonifacio (PF-7), a Philippine Navy frigate in commission from 1976 to 1985
- Transportation
- Bonifacio Transport Corporation, an intercity bus company operated by Fort Bonifacio Development Corp., a conglomerate company of Ayala Group of Companies, serving routes from Ayala Center, Makati City to Fort Bonifacio, Taguig City via McKinley Road.