Bledsoe is a surname. Notable people with the surname include:
- Albert Taylor Bledsoe (1809 – 1877), American educator, attorney, author, and clergyman
- Ben Bledsoe (born 1982), American pop singer
- Benjamin Franklin Bledsoe (1874 - 1938), American federal judge
- Curtis Bledsoe (born 1957), former American football player
- Drew Bledsoe (born 1972), former American football quarterback
- Eric Bledsoe (born 1989), American basketball player
- Fred Bledsoe (born 1986), American football defensive tackle
- Jerry Bledsoe (born 1941), American author and journalist
- Jesse Bledsoe (1776 - 1836), Senator from Kentucky
- Jules Bledsoe (1898 - 1943), African American singer
- Lucy Jane Bledsoe (born 1957), American novelist and science writer
- Samuel T. Bledsoe (1868 - 1939), American railroad executive
- Tempestt Bledsoe (born 1973), American actress
- Tim Bledsoe (born 1953), American politician and college professor
- Woody Bledsoe (1921 - 1995), American mathematician and computer scientist
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