History
Before the 1950s, opioids, and amphetamines, were commonly used as antidepressants. Their use was later restricted due to their addictive nature and side-effects. Extracts from the herb St John's wort had been used as a "nerve tonic" to alleviate depression.
Read more about this topic: Bicyclic Antidepressants
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—Henry David Thoreau (1817–1862)
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