History
Before the 1950s, opioids, and amphetamines, were commonly used as antidepressants. Their use was later restricted due to their addictive nature and side-effects. Extracts from the herb St John's wort had been used as a "nerve tonic" to alleviate depression.
Read more about this topic: Bicyclic Antidepressants
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“The disadvantage of men not knowing the past is that they do not know the present. History is a hill or high point of vantage, from which alone men see the town in which they live or the age in which they are living.”
—Gilbert Keith Chesterton (1874–1936)
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—Ralph Waldo Emerson (1803–1882)