Baylis is a surname, and may refer to:
- Jearld Baylis, a star defensive lineman in the Canadian Football League
- Julie Baylis, wife of The Honourable Jeremy Lascelles
- Keith Baylis (born 1947), English former cricketer
- Lilian Baylis (1874–1937), British theatrical producer, manager and founder of a ballet company
- Nick Baylis FRSA (based in Cambridge, England) loosely describes himself as a well-being explorer
- Trevor Baylis (born 1937), English inventor of the windup radio
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Baylis is also a place name and may refer to:
- Baylis, Illinois, a village in Pike County, Illinois, United States
- Baylis, the seat of Alexander Wedderburn, 1st Earl of Rosslyn near Salt Hill, Windsor where he died in 1805
- Baylis Road, a road in Lambeth, London, England
- Baylis Street, one of the main shopping streets in Wagga Wagga, New South Wales, Australia
- Baylis Court School, a girls' school in Slough, Berkshire, England
Other uses:
- Baylis–Hillman reaction, a reaction of an aldehyde and an α,β-unsaturated electron-withdrawing group catalyzed by DABCO (1,4-diazabicyclooctane) to give an allylic alcohol
- Aza-Baylis–Hillman reaction, the reaction of an α,β-unsaturated carbonyl compound with an imine in the presence of a nucleophile