Diseases
Some diseases result from a poorly functioning basement membrane. The cause can be genetic defects, injuries by the body's own immune system, or other mechanisms.
Genetic defects in the collagen fibers of the basement membrane cause Alport syndrome.
Non-collagenous domain basement membrane collagen type IV is autoantigen (target antigen) of autoantibodies in the autoimmune disease Goodpasture's syndrome.
A group of diseases stemming from improper function of basement membrane zone are united under the name epidermolysis bullosa.
Read more about this topic: Basement Membrane
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