AXIN1
| Gene Ontology | |
|---|---|
| Molecular function | • p53 binding • signal transducer activity • GTPase activator activity • protein binding • beta-catenin binding • protein C-terminus binding • enzyme binding • protein kinase binding • ubiquitin protein ligase binding • protein complex scaffold • identical protein binding • protein homodimerization activity • protein self-association • SMAD binding • armadillo repeat domain binding • I-SMAD binding • R-SMAD binding |
| Cellular component | • nucleus • cytoplasm • cytosol • cytoplasmic microtubule • plasma membrane • cell cortex • postsynaptic density • cytoplasmic membrane-bounded vesicle • lateral plasma membrane • beta-catenin destruction complex • cytoplasmic vesicle • perinuclear region of cytoplasm • cell periphery |
| Biological process | • protein polyubiquitination • in utero embryonic development • optic placode formation • positive regulation of protein phosphorylation • nucleocytoplasmic transport • apoptotic process • activation of JUN kinase activity • determination of left/right symmetry • sensory perception of sound • cell death • dorsal/ventral axis specification • positive regulation of peptidyl-threonine phosphorylation • forebrain anterior/posterior pattern specification • Wnt receptor signaling pathway involved in forebrain neuron fate commitment • protein catabolic process • negative regulation of Wnt receptor signaling pathway • positive regulation of transforming growth factor beta receptor signaling pathway • olfactory placode formation • cytoplasmic microtubule organization • positive regulation of protein ubiquitination • activation of protein kinase activity • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of peptidyl-serine phosphorylation • negative regulation of transcription elongation from RNA polymerase II promoter • regulation of catenin import into nucleus • termination of G-protein coupled receptor signaling pathway • positive regulation of GTPase activity • cellular protein complex assembly • negative regulation of fat cell differentiation • positive regulation of protein catabolic process • positive regulation of transcription, DNA-dependent • positive regulation of JNK cascade • embryonic eye morphogenesis • axial mesoderm formation • negative regulation of protein metabolic process • protein homooligomerization • positive regulation of ubiquitin-protein ligase activity • muscle cell development • canonical Wnt receptor signaling pathway • embryonic skeletal joint morphogenesis • canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation • cellular response to organic cyclic compound • genetic imprinting • negative regulation of canonical Wnt receptor signaling pathway • Wnt receptor signaling pathway involved in somitogenesis • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
| Sources: Amigo / QuickGO | |
0.34 – 0.4 Mb
26.14 – 26.2 Mb
Axin-1 is a protein that in humans is encoded by the AXIN1 gene.
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene.
Read more about AXIN1: Interactions