Autophagy and Caloric Restriction
Research suggests that autophagy is required for the lifespan-prolonging effects of caloric restriction. A 2010 French study of nematodes, mice and flies showed that inhibition of autophagy exposed cells to metabolic stress. Resveratrol and the dietary restriction prolonged the lifespan of normal, autophagy-proficient nematodes, but not of nematodes in which autophagy had been inhibited by knocking out Beclin 1 (a known autophagic modulator). Research is ongoing in this field.
Read more about this topic: Autophagy
Famous quotes containing the word restriction:
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—Selma H. Fraiberg (20th century)