APOA2

APOA2

Identifiers Symbols APOA2; Apo-AII; ApoA-II; apoAII External IDs OMIM: 107670 MGI: 88050 HomoloGene: 1242 GeneCards: APOA2 Gene

Gene Ontology
Molecular function lipid transporter activity
protein binding
phospholipid binding
high-density lipoprotein particle binding
lipid binding
cholesterol binding
cholesterol transporter activity
phosphatidylcholine binding
apolipoprotein receptor binding
protein homodimerization activity
protein heterodimerization activity
lipase inhibitor activity
phosphatidylcholine-sterol O-acyltransferase activator activity
high-density lipoprotein particle receptor binding
Cellular component extracellular region
endoplasmic reticulum lumen
very-low-density lipoprotein particle
high-density lipoprotein particle
spherical high-density lipoprotein particle
chylomicron
Biological process acute inflammatory response
negative regulation of cytokine secretion involved in immune response
protein folding
lipid metabolic process
triglyceride metabolic process
phosphatidylcholine biosynthetic process
cholesterol metabolic process
phospholipid catabolic process
response to glucose stimulus
positive regulation of cholesterol esterification
negative regulation of very-low-density lipoprotein particle remodeling
protein oxidation
peptidyl-methionine modification
virus-host interaction
regulation of intestinal cholesterol absorption
organ regeneration
regulation of protein stability
negative regulation of cholesterol transport
cholesterol efflux
phospholipid efflux
triglyceride-rich lipoprotein particle remodeling
low-density lipoprotein particle remodeling
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
lipoprotein metabolic process
response to drug
cholesterol homeostasis
response to estrogen stimulus
reverse cholesterol transport
cellular lipid metabolic process
small molecule metabolic process
positive regulation of interleukin-8 biosynthetic process
diacylglycerol catabolic process
negative regulation of lipid catabolic process
positive regulation of lipid catabolic process
response to glucocorticoid stimulus
negative regulation of lipase activity
negative regulation of cholesterol import
negative regulation of cholesterol transporter activity
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 336 11807 Ensembl ENSG00000158874 ENSMUSG00000005681 UniProt P02652 P09813 RefSeq (mRNA) NM_001643 NM_013474 RefSeq (protein) NP_001634 NP_038502 Location (UCSC) Chr 1:
161.19 – 161.19 Mb Chr 1:
171.23 – 171.23 Mb PubMed search
ApoA-II
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
Symbol ApoA-II
Pfam PF04711
InterPro IPR006801
SCOP 1l6k
SUPERFAMILY 1l6k
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.

Read more about APOA2:  Interactions, Interactive Pathway Map