APOA2
Gene Ontology | |
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Molecular function | • lipid transporter activity • protein binding • phospholipid binding • high-density lipoprotein particle binding • lipid binding • cholesterol binding • cholesterol transporter activity • phosphatidylcholine binding • apolipoprotein receptor binding • protein homodimerization activity • protein heterodimerization activity • lipase inhibitor activity • phosphatidylcholine-sterol O-acyltransferase activator activity • high-density lipoprotein particle receptor binding |
Cellular component | • extracellular region • endoplasmic reticulum lumen • very-low-density lipoprotein particle • high-density lipoprotein particle • spherical high-density lipoprotein particle • chylomicron |
Biological process | • acute inflammatory response • negative regulation of cytokine secretion involved in immune response • protein folding • lipid metabolic process • triglyceride metabolic process • phosphatidylcholine biosynthetic process • cholesterol metabolic process • phospholipid catabolic process • response to glucose stimulus • positive regulation of cholesterol esterification • negative regulation of very-low-density lipoprotein particle remodeling • protein oxidation • peptidyl-methionine modification • virus-host interaction • regulation of intestinal cholesterol absorption • organ regeneration • regulation of protein stability • negative regulation of cholesterol transport • cholesterol efflux • phospholipid efflux • triglyceride-rich lipoprotein particle remodeling • low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling • high-density lipoprotein particle assembly • high-density lipoprotein particle clearance • lipoprotein metabolic process • response to drug • cholesterol homeostasis • response to estrogen stimulus • reverse cholesterol transport • cellular lipid metabolic process • small molecule metabolic process • positive regulation of interleukin-8 biosynthetic process • diacylglycerol catabolic process • negative regulation of lipid catabolic process • positive regulation of lipid catabolic process • response to glucocorticoid stimulus • negative regulation of lipase activity • negative regulation of cholesterol import • negative regulation of cholesterol transporter activity |
Sources: Amigo / QuickGO |
161.19 – 161.19 Mb
171.23 – 171.23 Mb
ApoA-II | |||||||||
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structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions | |||||||||
Identifiers | |||||||||
Symbol | ApoA-II | ||||||||
Pfam | PF04711 | ||||||||
InterPro | IPR006801 | ||||||||
SCOP | 1l6k | ||||||||
SUPERFAMILY | 1l6k | ||||||||
Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. Read more about APOA2: Interactions, Interactive Pathway Map |