Apamea or Apameia is the name of several Hellenistic cities in western Asia, after Apama, the wife of Seleucus I Nicator:
- Apamea (Babylonia), on the Tigris near the Euphrates, precise location unknown, now in Iraq
- Apamea (Euphrates), in Osroene, opposite Zeugma on the Euphrates, now flooded by the Birecik Dam, Turkey
- Apamea (Media), in Media, near Laodicea (Nahavand, Iran), precise location unknown
- Apamea (Phrygia), formerly Kibotos, commercial center of Phrygia, near Celaenae, now at Dinar, Afyonkarahisar Province, Turkey
- Apamea (Sittacene), on the Tigris, precise location unknown, now in Iraq
- Apamea (Syria), on the Orontes River, northwest of Hama, Syria
- Apamea Myrlea, formerly Myrlea and Brylleion, in Bithynia, on the Sea of Marmara; currently near Mudanya, Bursa Province, Turkey
- Apamea Ragiana, south of the Caspian Gates in Parthia (later Media); now in Iran
Apamea may also refer to:
- Apamea (moth genus)