Professional Boxing Record
| 38 Wins (27 knockouts, 11 decisions), 8 Losses (2 knockouts, 6 decisions), 0 Draws | |||||||
| Res. | Record | Opponent | Type | Rd., Time | Date | Location | Notes |
| Loss | 38–8-(1) | Miguel Cotto | TKO | 10 (12), 0:03 | 2011-12-03 | Madison Square Garden, New York, New York | For WBA (Super) Light Middleweight title. |
| Loss | 38–7-(1) | Manny Pacquiao | UD | 12 | 2010-11-13 | Cowboys Stadium, Arlington, Texas | For vacant WBC Light Middleweight title. |
| Win | 38–6-(1) | Roberto García | UD | 10 | 2010-05-08 | Plaza de Toros, Aguascalientes, Aguascalientes, Aguascalientes | Won WBC International Light Middleweight title. |
| Loss | 37–6-(1) | Shane Mosley | TKO | 9 (12), 0:43 | 2009-01-24 | Staples Center, Los Angeles, California | Lost WBA (Super) Welterweight title. |
| Win | 37–5-(1) | Miguel Cotto | TKO | 11 (12), 2:05 | 2008-07-26 | MGM Grand, Las Vegas, Nevada | Won WBA Welterweight title. |
| Win | 36–5-(1) | Kermit Cintrón | KO | 6 (12), 1:57 | 2008-04-12 | Boardwalk Hall, Atlantic City, New Jersey | Won IBF Welterweight title. |
| Win | 35–5-(1) | Golden Johnson | TKO | 1 (12), 2:28 | 2007-11-10 | Madison Square Garden, Madison Square Garden, New York, New York | Won vacant WBO Inter-Continental Welterweight title. |
| Loss | 34–5-(1) | Paul Williams | UD | 12 | 2007-07-14 | Home Depot Center, Carson, California | Lost WBO Welterweight title. |
| Win | 34–4-(1) | Joshua Clottey | UD | 12 | 2006-12-02 | Boardwalk Hall, Atlantic City, New Jersey | Retained WBO Welterweight title. |
| Win | 33–4-(1) | Manuel Gomez | TKO | 1 (12), 1:14 | 2006-02-18 | The Aladdin, Las Vegas, Nevada | Retained WBO Welterweight title. |
| Win | 32–4-(1) | Kermit Cintrón | TKO | 5 (12), 2:12 | 2005-04-23 | Caesar's Palace, Las Vegas, Nevada | Retained WBO Welterweight title. |
| Win | 31–4-(1) | Sebastian Lujan | TKO | 10 (12), 2:57 | 2005-02-18 | Boardwalk Hall, Atlantic City, New Jersey | Retained WBO Welterweight title. |
| Loss | 30–4-(1) | Daniel Santos | TD | 10 (12), 3:00 | 2004-09-11 | Coliseo Jose Miguel Agrelot, Hato Rey | For WBO Light Middleweight title. |
| Win | 30–3-(1) | Hercules Kyvelos | TD | 2 (12), 0:54 | 2004-01-31 | Dodge Theater, Phoenix, Arizona, Arizona | Retained WBO Welterweight title. |
| Win | 29–3-(1) | Maurice Brantley | TKO | 2 (10), 2:47 | 2003-10-17 | Celebrity Theater, Phoenix, Arizona | |
| Win | 28–3-(1) | Andrew Lewis | TD | 2 (12), 2:31 | 2003-02-08 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | Retained WBO Welterweight title. |
| Win | 27–3-(1) | Danny Pérez | UD | 12 | 2002-10-12 | Arrowhead Pond, Anaheim, California | Retained WBO Welterweight title. |
| Win | 26–3-(1) | Antonio Díaz | TKO | 10 (12), 2:17 | 2002-03-16 | Bally's Las Vegas, Las Vegas, Nevada | Won vacant WBO Welterweight title. |
| NC | 25–3-(1) | Daniel Santos | NC | 1 (12), 2:11 | 2001-07-21 | Coliseo Ruben Rodriguez, Bayamon | For WBO Welterweight title. |
| Win | 25–3 | Robert West | KO | 1 (10), 2:19 | 2001-03-30 | Convention Center, Fort Worth, Texas | |
| Win | 24–3 | Frankie Randall | RTD | 4 (10), 3:00 | 2000-12-10 | Memphis, Tennessee | |
| Win | 23–3 | José Luis Benítez | TKO | 1 (4), 1:06 | 2000-09-17 | El Gran Mercado, Phoenix, Arizona | |
| Win | 22–3 | David Kamau | TKO | 2 (12), 2:59 | 2000-06-16 | Fantasy Springs Resort Casino, Indio, California | Won WBO NABO Welterweight title. |
| Win | 21–3 | Sergio Martínez | TKO | 7 (10), 2:57 | 2000-02-19 | Mandalay Bay Resort & Casino, Las Vegas, Nevada | |
| Win | 20–3 | Efrain Munoz | KO | 2 (10) | 1999-12-15 | Quiet Cannon, Montebello, California | |
| Win | 19–3 | Buck Smith | TKO | 5 (8) | 1999-10-23 | Will Rogers Coliseum, Fort Worth, Texas | |
| Win | 18–3 | Danny Perez | SD | 8 | 1999-06-12 | Fantasy Springs Casino, Indio, California | |
| Win | 17–3 | Daniel Mendez | KO | 3 (8) | 1999-06-07 | Auditorio Municipal, Tijuana, Baja California | |
| Win | 16–3 | Reyes Estrada | KO | 2 (8) | 1998-12-04 | Auditorio Municipal, Tijuana, Baja California | |
| Win | 15–3 | Javier Francisco Mendez | KO | 10 | 1998-06-27 | Fantasy Springs Casino, Indio, California | |
| Win | 14–3 | Miguel Gonzalez | UD | 8 | 1998-04-24 | Scottish Rite Center, San Diego, California | |
| Win | 13–3 | Cesar Valdez | TKO | 5 (10) | 1997-11-29 | Orleans Hotel & Casino, Las Vegas, Nevada | |
| Win | 12–3 | Horatio Garcia | UD | 10 | 1997-06-26 | Country Club, Reseda, California | |
| Win | 11–3 | Juan Soberanes | UD | 10 | 1996-12-02 | Arrowhead Pond, Anaheim, California | |
| Win | 10–3 | Alfred Ankamah | KO | 4 (10) | 1996-10-14 | Arrowhead Pond, Anaheim, California | |
| Loss | 9–3 | Rodney Jones | UD | 10 | 1996-06-28 | Culver City, California | |
| Win | 9–2 | Juan Yoani Cervantes | KO | 4 (10) | 1996-04-18 | Los Angeles, California | |
| Loss | 8–2 | Larry Dixon | UD | 10 | 1996-02-26 | Tijuana, Baja California | |
| Win | 8–1 | Antonio Ojeda | KO | 4 (6) | 1995-09-10 | Tijuana, Baja California | |
| Win | 7–1 | Carlos Palafox | UD | 4 | 1995-03-18 | Tijuana, Baja California | |
| Win | 6–1 | Efrain Munoz | UD | 4 | 1995-01-26 | Tijuana, Baja California | |
| Loss | 5–1 | Victor Lozoya | UD | 6 | 1994-10-17 | Tijuana, Baja California | |
| Win | 5–0 | Francisco Lopez | TKO | 3 (4) | 1994-08-05 | Ensenada, Baja California | |
| Win | 4–0 | Cesar Roland | KO | 1 (4) | 1994-06-27 | Tijuana, Baja California | |
| Win | 3–0 | Victor Angulo | TKO | 4 | 1994-04-25 | Tijuana, Baja California | |
| Win | 2–0 | Gilberto Plata | UD | 4 | 1994-01-21 | Tijuana, Baja California | |
| Win | 1–0 | Jose Trujillo | UD | 4 | 1994-01-14 | Tijuana, Baja California | Margarito's professional debut. |
Read more about this topic: Antonio Margarito
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