Antiviral Drug - Acquired Resistance

Acquired Resistance

Almost all anti-microbials, including anti-virals, are subject to drug resistance as the pathogens mutate over time, becoming less susceptible to the treatment. For instance, a recent study published in Nature Biotechnology emphasized the urgent need for augmentation of oseltamivir (Tamiflu) stockpiles with additional antiviral drugs including zanamivir (Relenza) based on an evaluation of the performance of these drugs in the scenario that the 2009 H1N1 'Swine Flu' neuraminidase (NA) were to acquire the tamiflu-resistance (His274Tyr) mutation which is currently widespread in seasonal H1N1 strains.

Read more about this topic:  Antiviral Drug

Famous quotes containing the words acquired and/or resistance:

    When I contemplate the accumulation of guilt and remorse which, like a garbage-can, I carry through life, and which is fed not only by the lightest action but by the most harmless pleasure, I feel Man to be of all living things the most biologically incompetent and ill-organized. Why has he acquired a seventy years’ life-span only to poison it incurably by the mere being of himself? Why has he thrown Conscience, like a dead rat, to putrefy in the well?
    Cyril Connolly (1903–1974)

    High treason, when it is resistance to tyranny here below, has its origin in, and is first committed by, the power that makes and forever re-creates man.
    Henry David Thoreau (1817–1862)