Antigonus, a Greek name meaning "comparable to his father" or "worthy of his father", may refer to:
- Three Macedonian kings of the Antigonid dynasty that succeeded Alexander the Great in Asia:
- Antigonus I Monophthalmus (382–301 BC)
- Antigonus II Gonatas (319–239 BC)
- Antigonus III Doson (263–221 BC)
- Antigonos (son of Callas) Macedonian hetairos and athlete
- Antigonus of Carystus, 3rd century BC Greek writer on various subjects
- Antigonus of Sokho, Jewish scholar of the third century BC.
- Antigonus II Mattathias (died 37 BC), the last ruler of the Hasmonean kingdom of Judea
- Antigonus (butterfly), a genus of skipper butterflies