Anticipation (genetics)
In genetics, anticipation is a phenomenon whereby the symptoms of a genetic disorder become apparent at an earlier age as it is passed on to the next generation. In most cases, an increase of severity of symptoms is also noted. Anticipation is common in trinucleotide repeat disorders such as Huntington's disease and myotonic dystrophy where a dynamic mutation in DNA occurs. All of these diseases have neurological symptoms. Prior to the understanding of the genetic mechanism for anticipation, it was debated whether anticipation was a true biological phenomenon or whether the earlier age of diagnosis was related to heightened awareness of disease symptoms within a family.
Read more about Anticipation (genetics): Trinucleotide Repeats and Expansion, Disease Mechanisms, Examples of Diseases Showing Anticipation
Famous quotes containing the word anticipation:
“In the wildest nature, there is not only the material of the most cultivated life, and a sort of anticipation of the last result, but a greater refinement already than is ever attained by man.... Nature is prepared to welcome into her scenery the finest work of human art, for she is herself an art so cunning that the artist never appears in his work.”
—Henry David Thoreau (1817–1862)