Annihilator may refer to:
- To defeat something, demolish, get rid of
- Annihilator (ring theory), a mathematical concept
- The annihilator of a vector subspace
- Annihilator method, a type of differential operator, used in a particular method for solving differential equations
- Annihilator (band), a Canadian thrash metal band
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- Annihilator (album), a 2010 album by the band
- Annihilator (truck), a monster truck
- Annihilator (Justice League), a fictional automaton appearing in the series, Justice League Unlimited, possibly based on the Imperiex character
- Annihilator (TV film), a 1986 television movie starring Mark Lindsay Chapman
- Annihilator (Helicopter), a helicopter from the video game Grand Theft Auto IV