Animal Models of Ischemic Stroke - Mechanisms of Inducing Ischemic Stroke

Mechanisms of Inducing Ischemic Stroke

Some of the mechanisms which have been used are:

  • Complete global ischemia
    • Decapitation
    • Aorta/vena cava occlusion
    • External neck torniquet or cuff
    • Cardiac arrest
  • Incomplete global ischemia
    • Hemorrhage or hypotension
    • Hypoxic ischemia
    • Intracranial hypertension and common carotid artery occlusion
    • Two-vessel occlusion and hypotension
    • Four-vessel occlusion
    • Unilateral common carotid artery occlusion (in some species only)
  • Focal cerebral ischemia
    • Endothelin-1-induced constriction of arteries and veins
    • Middle cerebral artery occlusion
    • Spontaneous brain infarction (in spontaneously hypertensive rats)
    • Macrosphere embolization
  • Multifocal cerebral ischemia
    • Blood clot embolization
    • Microsphere embolization
    • Photothrombosis

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Famous quotes containing the word stroke:

    We are double-edged blades, and every time we whet our virtue the return stroke straps our vice. Where is the skillful swordsman who can give clean wounds, and not rip up his work with the other edge?
    Henry David Thoreau (1817–1862)