Animal Models of Ischemic Stroke - Mechanisms of Inducing Ischemic Stroke

Mechanisms of Inducing Ischemic Stroke

Some of the mechanisms which have been used are:

  • Complete global ischemia
    • Decapitation
    • Aorta/vena cava occlusion
    • External neck torniquet or cuff
    • Cardiac arrest
  • Incomplete global ischemia
    • Hemorrhage or hypotension
    • Hypoxic ischemia
    • Intracranial hypertension and common carotid artery occlusion
    • Two-vessel occlusion and hypotension
    • Four-vessel occlusion
    • Unilateral common carotid artery occlusion (in some species only)
  • Focal cerebral ischemia
    • Endothelin-1-induced constriction of arteries and veins
    • Middle cerebral artery occlusion
    • Spontaneous brain infarction (in spontaneously hypertensive rats)
    • Macrosphere embolization
  • Multifocal cerebral ischemia
    • Blood clot embolization
    • Microsphere embolization
    • Photothrombosis

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