Cast
- Charlie Sheen - Charlie B. Barkin, who returns from Heaven to retrieve Gabriel's Horn. (Jesse Corti - his singing voice)
- Dom DeLuise - Itchy Itchiford, Charlie's best friend. He only wants to do what he was sent to do and go back to Heaven.
- Sheena Easton - Sasha La Fleur, a pretty lounge singer and Charlie's love interest.
- Adam Wylie - David, Sasha's owner, an 8-year-old lonely human boy. He believes that Charlie and Itchy are his guardian angels sent to get him back home.
- George Hearn - Red: He is a powerful demonic catlike monster who disguises himself as an elderly dog who plans to imprison the dogs in Heaven and drag them to Hell.
- Bebe Neuwirth - Annabelle, the archangel dog in Heaven. She summons Charlie and Itchy back to Heaven to retrieve Gabriel's Horn.
- Ernest Borgnine - Carface Carruthers, Charlie and Itchy's old nemesis and Red's sidekick. He is much less menacing and evil than he appeared to be in the original. This time, he is more clumsy and dimwitted, providing much comic relief.
- Wallace Shawn - Labrador MC, the sleazy MC at Sasha's lounge
- Hamilton Camp - Chihuahua
- Dan Castellaneta - Tall Customs Dog
- Pat Corley - Officer McDowell
- Jim Cummings - Jingles, a Yorkshire Terrier who got kicked out of the sing-off, but was given the 1st place bone by Sasha.
- Bobby Di Cicco - Tom
- Annette Helde - Claire
- Marabina Jaimes - Officer Reyes
- Tony Jay - Reginald
- Maurice LaMarche - Lost & Found Officer
- Steve Mackall - Short Customs Dog
- Kevin Michael Richardson - Ace the St. Bernard
Read more about this topic: All Dogs Go To Heaven 2
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