Function
The aldose reductase reaction, in particular the sorbitol produced, is important for the function of various organs in the body. For example, it is generally used as the first step in a synthesis of fructose from glucose; the second step is the oxidation of sorbitol to fructose catalyzed by sorbitol dehydrogenase. The main pathway from glucose to fructose (glycolysis) involves phosphorylation of glucose by hexokinase to form glucose 6-phosphate, followed by isomerization to fructose 6-phosphate and hydrolysis of the phosphate, but the sorbitol pathway is useful because it does not require the input of energy in the form of ATP:
- Seminal vesicles: Fructose produced from sorbitol is used by the sperm cells.
- Liver: Fructose produced from sorbitol can be used as an energy source for glycolysis and glyconeogenesis.
Aldose reductase is also present in the lens, retina, Schwann cells of peripheral nerves, placenta and red blood cells.
Read more about this topic: Aldose Reductase
Famous quotes containing the word function:
“Science has fulfilled her function when she has ascertained and enunciated truth.”
—Thomas Henry Huxley (1825–95)
“Uses are always much broader than functions, and usually far less contentious. The word function carries overtones of purpose and propriety, of concern with why something was developed rather than with how it has actually been found useful. The function of automobiles is to transport people and objects, but they are used for a variety of other purposes—as homes, offices, bedrooms, henhouses, jetties, breakwaters, even offensive weapons.”
—Frank Smith (b. 1928)
“It is not the function of our Government to keep the citizen from falling into error; it is the function of the citizen to keep the Government from falling into error.”
—Robert H. [Houghwout] Jackson (1892–1954)