Polyol Pathway
Also called the sorbitol-aldose reductase pathway, the polyol pathway appears to be implicated in diabetic complications, especially in microvascular damage to the retina, kidney, and nerves.
Sorbitol cannot cross cell membranes, and, when it accumulates, it produces osmotic stresses on cells by drawing water into the insulin-independent tissues.
Famous quotes containing the word pathway:
“Many are obstinate with regard to the pathway once they have set upon it, few with regard to the goal.”
—Friedrich Nietzsche (1844–1900)