Biological Aldol Reactions
Examples of aldol reactions in biochemistry include the splitting of fructose-1,6-bisphosphate into dihydroxyacetone and glyceraldehyde-3-phosphate in the second stage of glycolysis, which is an example of a reverse ("retro") aldol reaction catalyzed by the enzyme aldolase A (also known as fructose-1,6-bisphosphate aldolase).
In the glyoxylate cycle of plants and some prokaryotes, isocitrate lyase produces glyoxylate and succinate from isocitrate. Following deprotonation of the OH group, isocitrate lyase cleaves isocitrate into the four-carbon succinate and the two-carbon glyoxylate via an aldol cleavage reaction. This cleavage is very similar mechanistically to the aldolase A reaction of glycolysis.
Read more about this topic: Aldol Reaction
Famous quotes containing the words biological and/or reactions:
“No poetic phantasy
but a biological reality,
a fact: I am an entity
like bird, insect, plant
or sea-plant cell;
I live; I am alive.”
—Hilda Doolittle (1886–1961)
“Prolonged, indiscriminate reviewing of books is a quite exceptionally thankless, irritating and exhausting job. It not only involves praising trash but constantly inventing reactions towards books about which one has no spontaneous feeling whatever.”
—George Orwell (1903–1950)