The Setting
The primary antagonists of the series was a group known as The Brotherhood. They were a highly secretive organization formed by remnants of the legendary lost civilization of Lemuria. Lemuria had been an advanced civilization in the prehistoric age of mankind.
Lemuria was destroyed by ravaging horde of primitive barbarians. The survivors who escaped established a hidden base whereby they dedicated themselves to preserving their advanced knowledge, keeping their existence a secret from the world, but maintaining a network of agents working surreptitiously amongst the rulers.
Through actions of these agents, the Brotherhood kept an eye on the development of the world, intervening through indirect and subtle means to guide the course of history, and when they judged the time was ready, gradually release bits of knowledge, such as specific scientific breakthroughs, to the world.
In the story, the secret agents of the Brotherhood were responsible for preventing the sacking of Rome by Attila the Hun in AD 452, as well as being responsible for the advancements during the Renaissance.
It was not revealed, at first, when corruption set in, or whether it had been there from the beginning. Eventually, Itsu, known as the Hand Sinister, one of the paramount leaders of the Brotherhood, seized full control of the Brotherhood, and began using it as a tool to dominate the world. Its agents acted to infiltrate the major governments of the world and set the world on a path towards globally destructive war, which would give them the opportunity to become its master.
Read more about this topic: Agent 13: The Midnight Avenger
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