Background
Fluoroquinolones are often effective as antibacterial agents. They are recommended for a number of serious bacterial infections, and, in some cases of life-threatening infections, they can be life-saving. The distinction between a quinolone drug and a fluoroquinolone drug is the addition of the fluorine atom to the basic pharmacophore, resulting in a fluorinated drug. The terms fluoroquinolone and quinolone are often used interchangeably, without regard to this distinction.
A meta-analysis for fluoroquinolones and skin infections found that fluoroquinolones are associated with more adverse reactions than beta lactams. However the increase was due to a higher rate of mild to moderate nausea and diarrhea. Side effects severe enough to cause withdrawal from the clinical trial occurred at similar rates.
Rarely, fluoroquinolone antibiotics have been associated with serious and detrimental effects on the musculoskeletal system, cardiovascular system, CNS and peripheral nervous system, circulatory system, maxillofacial system, endocrine system, gastrointestinal system, urological system, the liver, the brain, the skin, and the sensory systems; hearing, sight, taste, touch, and smell. Toxic reactions have been reported to occur after a single dose.
Read more about this topic: Adverse Effects Of Fluoroquinolones
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