Commercial Availability
The first commercially available adhesion barrier it seems was Cargile Membrane, a preserved peritoneal membrane of the Danish Ox. Marketed by Johnson & Johnson around 1904, it was still available in the early 1990s. In the United States, Interceed, Seprafilm and Adept are the three products approved by FDA for use as an adhesion barrier after abdominal or pelvic surgery.
Seprafilm (made by Genzyme) is a clear, sticky film composed of chemically modified sugars, some of which occur naturally in the human body. It sticks to the tissues to which it is applied and is slowly absorbed into the body over a period of seven days. It is approved for use in certain types of pelvic or abdominal surgery.
Interceed (made by Johnson & Johnson) is a knitted fabric composed of a modified cellulose that swells and eventually gels after being placed on the injured site, and, like Seprafilm, forms a barrier and then is slowly absorbed over a period of days. It is approved for use in pelvic surgery. Although it is technically possible to apply either Seprafilm and Interceed laparoscopically, neither product is approved for this use in the USA.
Adept (Baxter) is a solution of Icodextrin that when instilled in a large volume causes organs to float apart, reducing the possibility of attachment.
Read more about this topic: Adhesion Barrier
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