ADAM17

ADAM17

Identifiers Symbols ADAM17; ADAM18; CD156B; CSVP; NISBD; TACE External IDs OMIM: 603639 MGI: 1096335 HomoloGene: 2395 ChEMBL: 3706 GeneCards: ADAM17 Gene EC number 3.4.24.86

Gene Ontology
Molecular function	• metalloendopeptidase activity • interleukin-6 receptor binding • integrin binding • protein binding • metallopeptidase activity • zinc ion binding • SH3 domain binding • PDZ domain binding • metal ion binding
Cellular component	• cytoplasm • plasma membrane • integral to plasma membrane • cell-cell junction • focal adhesion • cell surface • actin cytoskeleton • apical plasma membrane • ruffle membrane • membrane raft
Biological process	• response to hypoxia • positive regulation of protein phosphorylation • neutrophil mediated immunity • germinal center formation • positive regulation of leukocyte chemotaxis • membrane protein ectodomain proteolysis • cell adhesion • epidermal growth factor receptor signaling pathway • Notch signaling pathway • positive regulation of cell proliferation • positive regulation of T cell chemotaxis • B cell differentiation • positive regulation of cell growth • positive regulation of cell migration • positive regulation of transforming growth factor beta receptor signaling pathway • membrane protein intracellular domain proteolysis • positive regulation of cyclin-dependent protein kinase activity involved in G1/S • response to lipopolysaccharide • negative regulation of interleukin-8 production • positive regulation of chemokine production • regulation of mast cell apoptotic process • T cell differentiation in thymus • cell adhesion mediated by integrin • wound healing, spreading of epidermal cells • epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway • response to drug • positive regulation of epidermal growth factor-activated receptor activity • nerve growth factor receptor signaling pathway • spleen development • cell motility • PMA-inducible membrane protein ectodomain proteolysis • positive regulation of cellular component movement • response to high density lipoprotein particle stimulus • JAK-STAT cascade involved in growth hormone signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6868 11491 Ensembl ENSG00000151694 ENSMUSG00000052593 UniProt P78536 Q9Z0F8 RefSeq (mRNA) NM_003183.4 NM_009615.5 RefSeq (protein) NP_003174.3 NP_033745.4 Location (UCSC) Chr 2:
9.63 – 9.7 Mb Chr 12:
21.32 – 21.37 Mb PubMed search

ADAM metallopeptidase domain 17 (ADAM17), also called TACE (tumor necrosis factor-α-converting enzyme), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases.