ACVR1

ACVR1

Identifiers Symbols ACVR1; ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI External IDs OMIM: 102576 MGI: 87911 HomoloGene: 7 ChEMBL: 5903 GeneCards: ACVR1 Gene EC number 2.7.11.30

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • receptor signaling protein serine/threonine kinase activity • transforming growth factor beta receptor activity, type I • protein binding • ATP binding • activin receptor activity, type I • peptide hormone binding • protein homodimerization activity • SMAD binding • metal ion binding • activin binding • transforming growth factor beta binding
Cellular component	• integral to plasma membrane • apical part of cell • activin receptor complex
Biological process	• G1/S transition of mitotic cell cycle • patterning of blood vessels • urogenital system development • in utero embryonic development • gastrulation with mouth forming second • mesoderm formation • neural crest cell migration • acute inflammatory response • embryonic heart tube morphogenesis • mitral valve morphogenesis • atrial septum primum morphogenesis • protein phosphorylation • transforming growth factor beta receptor signaling pathway • germ cell development • determination of left/right symmetry • negative regulation of signal transduction • positive regulation of pathway-restricted SMAD protein phosphorylation • peptidyl-threonine phosphorylation • regulation of ossification • positive regulation of bone mineralization • BMP signaling pathway • activin receptor signaling pathway • negative regulation of activin receptor signaling pathway • negative regulation of apoptotic process • positive regulation of osteoblast differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of skeletal muscle tissue development • smooth muscle cell differentiation • pharyngeal system development • pathway-restricted SMAD protein phosphorylation • cardiac muscle cell fate commitment • endocardial cushion cell fate commitment • cellular response to glucocorticoid stimulus • positive regulation of determination of dorsal identity
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 90 11477 Ensembl ENSG00000115170 ENSMUSG00000026836 UniProt Q04771 P37172 RefSeq (mRNA) NM_001105.4 NM_001110204.1 RefSeq (protein) NP_001096.1 NP_001103674.1 Location (UCSC) Chr 2:
158.59 – 158.73 Mb Chr 2:
58.39 – 58.57 Mb PubMed search

Activin A receptor, type I (ACVR1) also known as ALK-2 is a protein which in humans is encoded by the ACVR1 gene.