Role in Virus Endocytosis
5-HT2A may be a necessary receptor for clathrin mediated endocytosis of the human polyoma virus called JC virus, the causative agent of progressive multifocal leukoencephalopathy (PML), that enters cells such as oligodendrocytes, astrocytes, B lymphocytes, and kidney epithelial cells. These cells need to express both the alpha 2-6–linked sialic acid component of the 5HT2A receptor in order to endocytose JCV.
Read more about this topic: 5-HT2A Receptor
Famous quotes containing the words role and/or virus:
“Where we come from in America no longer signifies—it’s where we go, and what we do when we get there, that tells us who we are.
The irony of the role of women in my business, and in so many other places, too, was that while we began by demanding that we be allowed to mimic the ways of men, we wound up knowing we would have to change those ways. Not only because those ways were not like ours, but because they simply did not work.”
—Anna Quindlen (b. 1952)
“Think of the earth as a living organism that is being attacked by billions of bacteria whose numbers double every forty years. Either the host dies, or the virus dies, or both die.”
—Gore Vidal (b. 1925)