5-HT2A Receptor - Effects

Effects

Physiological processes mediated by the receptor include:

  • CNS: neuronal excitation, behavioural effects, learning, anxiety
  • smooth muscle: contraction (in gastrointestinal tract & bronchi)
  • vasoconstriction / vasodilatation
  • platelets: aggregation
  • Activation of the 5-HT2A receptor with DOI produces superpotent anti-inflammatory effects in cardiovascular related tissues, as well as potent anti-inflammatory effects in non-cardiovascular tissues. Other 5-HT2A agonists like LSD also have potent anti-inflammatory effects against TNF-alpha-induced inflammation.
  • Activation of the 5-HT2A receptor in hypothalamus causes increases in hormonal levels of oxytocin, prolactin, ACTH, corticosterone, and renin.

Read more about this topic:  5-HT2A Receptor

Famous quotes containing the word effects:

    “If one judges love according to the greatest part of the effects it produces, it would appear to resemble rather hatred than kindness.”
    —François, Duc De La Rochefoucauld (1613–1680)

    “Whereas Freud was for the most part concerned with the morbid effects of unconscious repression, Jung was more interested in the manifestations of unconscious expression, first in the dream and eventually in all the more orderly products of religion and art and morals.”
    —Lewis Mumford (1895–1990)

    “The ultimate result of shielding men from the effects of folly, is to fill the world with fools.”
    —Herbert Spencer (1820–1903)