21-hydroxylase

21-Hydroxylase

Identifiers Symbols CYP21A2; CA21H; CAH1; CPS1; CYP21; CYP21B; P450c21B External IDs OMIM: 613815 MGI: 88591 HomoloGene: 68063 ChEMBL: 2759 GeneCards: CYP21A2 Gene EC number 1.14.99.10

Gene Ontology
Molecular function	• steroid 21-monooxygenase activity • steroid binding • iron ion binding • steroid hydroxylase activity • electron carrier activity • heme binding
Cellular component	• endoplasmic reticulum membrane
Biological process	• glucocorticoid biosynthetic process • mineralocorticoid biosynthetic process • xenobiotic metabolic process • steroid metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1589 13079 Ensembl ENSG00000198457 ENSMUSG00000024365 UniProt P08686 P03940 RefSeq (mRNA) NM_000500.7 NM_009995.2 RefSeq (protein) NP_000491.4 NP_034125.2 Location (UCSC) Chr 6:
32.01 – 32.01 Mb Chr 17:
34.8 – 34.8 Mb PubMed search

Steroid 21-hydroxylase is a cytochrome P450 enzyme that is involved with the biosynthesis of the steroid hormones aldosterone and cortisol.